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Peña Plastic Surgery

Board-Certified Plastic Surgeon

239-348-7362
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      • About Manuel Peña, M.D.
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  • Results
    • Face & Injectables
      • Facelift
      • Rhinoplasty
      • Lip Augmentation
      • Dermal Fillers / Injectables
    • Breast Procedures
      • Breast Augmentation
      • Breast Lift
      • Breast Reduction
    • Body Contouring Procedures
      • Arm Lift
      • Body Contouring
      • Liposuction
      • Mommy Makeover
      • Tummy Tuck
    • Laser & RF Energy Procedures
      • Laser Rejuvenation Gallery
      • Sofwave™ Gallery
      • ThermiTight™ Gallery
      • ThermiVa™ Gallery
  • Surgical
    • Face Enhancements
      • Brow Lift
      • Eyelid Lift (Blepharoplasty)
      • Facelift (Mini or S-lift)
      • Facelift (Full)
      • Facial Fat Grafting
      • Facial Implants
      • Lip Augmentation
      • Nose Shaping (Rhinoplasty)
      • Neck Lift & Thread Lift
      • Otoplasty (Ear Pinning)
      • Gauging & Earlobe Repair
    • Body Contouring
      • Abdominoplasty (Tummy Tuck)
      • Arm Lift (Brachioplasty)
      • Body Lift
      • Fat Grafting
      • Liposuction
      • Mommy Makeover
      • Post-Bariatric Body Contouring
    • Breast Enhancements
      • Breast Augmentation
      • Breast Lift
      • Breast Implant Removal, Lift & Fat Grafts
      • Breast Asymmetry
      • Female Breast Reduction
      • Male Breast Reduction
  • Non-surgical
    • Injectables
      • BOTOX® Cosmetic
      • DAXXIFY®
      • Dysport®
      • Microneedling (Innopen™)
      • Microneedling (PRP)
      • Juvéderm® Ultra XC / Ultra Plus XC
      • Juvéderm® Volbella™ XC
      • Juvéderm® Vollure XC
      • Juvéderm® Voluma™ XC
      • Lip Augmentation
      • PRO-NOX™
      • PRP Facial & Fat Replacement
      • Radiesse®
      • Restylane-L®
      • Restylane® Defyne, Lyft Refyne & Silk
      • Restylane® Kysse
      • Sculptra® Aesthetic
      • Teoxane Fillers (RHA2, RHA3, RHA4)
    • Body Contouring & Rejuvenation
      • “Instant” Neck Lift
      • Skin Tightening (ThermiTight®)
      • SculpSure® Fat Reduction
      • Fractional Skin Resurfacing & Tightening (Morpheus8)
    • Specialized Services
      • Hair Restoration (Microneedling with PRP)
      • Vein Treatment Sclerotherapy
      • Vaginal Rejuvenaton (THERMIva)
    • Skin Care
      • HydraFacial MD®
      • Latisse® Eyelash Enhancement
      • La Piel Full-Service Medical Spa
      • Sofwave™
  • Laser RF Light Technology
    • Lasers & Radio Frequency (RF)
      • Fractional CO2 (SmartXide Dot™)
      • FaceTite Skin Tightening
      • Injectable & RF Skin Tightening (Accutite)
      • Laser Hair Removal
      • Facial Rejuvenation (ThermiSmooth®)
    • Light Sources
      • Intense Pulsed Light (IPL)
      • Lumecca IPL
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Fill Your Wrinkles and Enhance Your Lips

Restylane® Defyne, Lyft Refyne & Silk

Woman with full, beautiful faceDr. Manuel Peña offers his patients a variety of dermal filler injections, including the family of Restylane® Hyaluronic Acid (HA) injectable gel products. Manufactured by Galderma, these advanced long-lasting dermal fillers includes: Restylane®-L, Restylane® Refyne™, Defyne™, Lyft™, Silk, and the newest product Restylane® Kysse™.

Dr. Peña is pleased to offer the full line of Restylane® products as they are proven to help maintain natural movement and expression!

What Are Dermal Fillers

Dermal fillers are medical grade materials that are injected into your skin in order to repair wrinkles, lines, and scars. They are an excellent method of restoring facial volume. You will notice the results of your filler treatment almost immediately. They are minimally-invasive, cause minimal discomfort, and are performed in Dr. Peña’s office with no downtime. Any injection may cause temporary bruising and swelling!

A photo of a past patient
Five Star Rating
“Dr Peña is extremely caring and thorough. He is an excellent surgeon as well a wonderful injector! He was able to fix issues on my face that no one else could! He is very responsive and communicative. Love him!” - Elaine Falkenberg (Google Review)
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Where can Dermal Fillers be Injected?

Dermal fillers can be used to address age-related facial concerns and can be used enhance your lips and hands. The areas treated include:

  • Nasolabial folds
  • Cheek creases
  • Mid-facial lines
  • Lips
  • Marionette lines
  • Chin creases
  • Hollows under the eyes
  • Hands
  • Cheek hollows
  • Frown lines
  • Crow’s feet

What are the Restylane® Family of Products?

Restylane® boxes
The Restylane® family of injectable gels are FDA-approved products specially manufactured to address various age-related concerns. Facial concerns such as, wrinkles and folds, volume loss, fine lines and other age-related face and hand concerns. While the most common areas of interest for facial rejuvenation injectables are nasolabial folds, there are other advanced Restylane® products that can target a person’s non-surgical facial rejuvenation goals. The collection of Restylane® products include: Restylane-L®,Restylane® Defyne, Restylane® Lyft, Restylane® Refyne, Restylane® Silk, and Restylane® Kysse.

What is Restylane® Defyne?

Restylane® Defyne boxAs we age, our face loses volume and our skin loses elasticity which produces lines that run from your nose towards the corner of your mouth. Restylane® Defyne is specifically designed to smooth out deep laugh lines (nasolabial folds) and those moderate-to-severe smile lines. This filler is not only made up of hyaluronic acid (HA) but also the innovative XpresHAn Technology™ which cross-links the gel to help support your natural movement and facial expressions.

Restylane® Defyne has a less flexible formulation than Restylane® Refyne, and for that reason it provides the additional volume and support needed to treat severe wrinkles and folds while still allowing you to move effortlessly with facial expressions!

What is Restylane® Lyft?

Restylane® Lyft is an exciting hyaluronic acid (HA) filler. It is the first and only HA filler that is FDA-approved to address your face and hands volumizing and wrinkle reduction goals. This dermal filler produces natural-looking volume in your cheeks, midface area, and hands resulting in more youthful-looking appearance. An added plus is that you can rejuvenate your face and hands in just one appointment.

What is Restylane® Refyne?

Restylane® Refyne boxRestylane® Refyne is specifically designed to smooth out those irritating mild-to-moderate laugh lines (nasolabial folds) lines) and wrinkles. This filler uses hyaluronic acid (HA) as it’s active ingredient with the added, XpresHAn Technology™ which cross-links the gel to help support your natural facial expressions and movement.
The primary difference between Restylane® Defyne and Restylane® Refyne is that Refyne is used for mild-to-moderate wrinkles and general lines, while Restylane® Defyne treats moderate-to-severe smile lines.

What is Restylane® Silk?

Restylane® Silk boxRestylane® Silk is an injectable product that is designed for smoothing wrinkles and lines around the mouth, also known as ‘smoker’s lines.’ Restylane® Silk is also designed to augment the lips, making them appear fuller and more youthful. It is a smooth injectable that is formulated using a high concentration of cross-linked chains of HA. The HA particles are also smaller and smoother than those used in other Restylane® products. Because of the small size of the particles, the product can absorb water after it has been placed causing 24-48 hours of mild-to-moderate swelling!

Dr. Peña also offers Restylane-L® for tear toughs and Restylane® Kysse™ for lip enhancements at his Peña Plastic Surgery practice which is located in Naples, FL.

Restylane-L® box
Restylane® Kysse box

How are Restylane® Dermal Fillers Injected and What Results Can You Expect?

Injection skill, experience and technique matters! Dr. Peña performs all dermal filler injections on his patients. The injection process involves three steps:

  • Step One: Dr. Peña will carefully select the injection points on areas of the face or hand to be treated. If needed, an antiseptic is also applied.
  • Step Two: Dr. Peña then identifies the correct amount of the recommended Restylane® product to be injected, dependent upon the facial and/or hand rejuvenation desired.
  • Step Three: The filler is injected with a needle in the desired locations under the skin.

The treatment requires little to no downtime and most patients are able to return to their regular activities immediately after the injections.

Results from the Restylane® products vary dependent upon the product:

  • Restylane® Defyne results typically last for 12 months*
  • Restylane® Lyft results typically last between 10-18 months*
  • Restylane® Refyne results typically last for 12 months*
  • Restylane® Silk results typically last up to six months*
  • Restylane-L® in tear toughs can typically last several years*

Most of Dr. Peña’s patients only need one session to achieve maximum results, yet touch-up treatments are an option for those who want to achieve and maintain their desired facial enhancement.

Aspire Galderma Rewards logo

Join the Aspire Galderma Rewards Program

The ASPIRE Galderma Rewards program is free to join and is for patients who use Galderma aesthetic treatments. With ASPIRE, you will receive exclusive points and discounts and much more. Galderma aesthetic treatments include Dysport®, any of the Restylane® Family of HA fillers, and Sculptra® Aesthetic.

If you are interested in the facial rejuvenation effects of dermal injectables at Peña Plastic Surgery in Naples, FL, including the Restylane® Family of injectable gels, schedule a consultation.

*Individual results may vary. Consult with Dr. Peña to see if you are a candidate.

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Specials and Events

VI PEEL Special
Injection Day – December 3rd

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Before and After

Facelift Before and After Facelift Before and After Lip Augmentation Before and After Lip Augmentation Before and After Rhinoplasty Before and After Rhinoplasty Before and After Before and After Mommy Makeover Naples, FL Before and After Mommy Makeover Naples, FL ThermiTight Before and After ThermiTight Before and After
Individual results may vary. Click to View Results

Contact Us

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La Piel SPA Services & Injectables

Front of the La Piel Spa enterance

La Piel Spa – We also offer special services like facial chemical peels through La Piel Spa, our relaxing MediSpa. Our makeup specialists can work with you to show you the best makeup application techniques to enhance your appearance.

La Piel Full-Service Medical Spa Book at La Piel Spa
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Send Us a Message

Have a question? Click the Contact Us button to visit our contact page and send us an email, or call us at 239-348-7362. Our highly skilled professionals are ready to answer your questions. Dr. Peña is a board-certified plastic surgeon with over three decades of experience performing cosmetic procedures.

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Book An Appointment

We now offer more convenient, faster, easy access for booking consultations, injections and spa services. Click Book Now to schedule an appointment at Peña Plastic surgery center or La Piel Medspa.

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6370 Pine Ridge Rd. Suite 101,
Naples, FL 34119
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Peña Plastic Surgery

The staff at the office of Naples Cosmetic Surgeon, Manuel Peña, MD, is truly what sets our Naples cosmetic surgery practice apart from other Florida providers. Our highly skilled professionals will go above and beyond to make your experience an exceptional one.

Location
6370 Pine Ridge Rd. Suite 101, Naples, FL 34119

Call Today
239-348-7362

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Our Success Stories

"Dr. Peña and his entire staff were so great. Dr. Peña took a lot of time with me to find out exactly what I wanted done and what my concerns were, he answered all my questions and was very thorough."

- Donna Fettig

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May 5

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Happy Cinco De Mayo 🍹🪇

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Apr 26

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Cami our surgery tech is moving  and starting a new chapter. We will miss you and wish you the best. Good bye party 🥳 cowboy way.

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Apr 24

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Representing LaPiel Spa at ObagiMedical Training event

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Apr 19

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Behind the scenes 🎥🎬🍿

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Apr 15

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This weekend we celebrated Monica soon giving birth to our 4th grandson

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Apr 8

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3 days vs. 1 month post procedure. Full face Fractional CO2 laser resurfacing,Morpheus 8 and lip lift.
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Naples plastic surgeon, Dr. Manuel Peña’s website provides information on cosmetic surgery in the Naples, Fort Myers, Bonita Springs, & Estero, areas in Florida. This information is not to be taken as medical advice. Site powered by PUMC and AtlantisNet with copyrights reserved to dr-pena.com © 2025. This website does not contain medical advice and the use of this website does not create a physician/patient relationship between you and Dr. Manuel Peña. The photographs of models displayed on the headings and borders of this web site are for decorative purposes only. *Individual results may vary. Consult with Dr. Peña to see if you are a candidate. See before & after photos of Dr. Peña’s patients for possible results.